Coenzyme Q10 and spinocerebellar ataxias.
Identifieur interne : 000292 ( Main/Exploration ); précédent : 000291; suivant : 000293Coenzyme Q10 and spinocerebellar ataxias.
Auteurs : Raymond Y. Lo [Taïwan] ; Karla P. Figueroa ; Stefan M. Pulst ; Chi-Ying Lin ; Susan Perlman ; George Wilmot ; Christopher Gomez ; Jeremy Schmahmann ; Henry Paulson ; Vikram G. Shakkottai ; Sarah Ying ; Theresa Zesiewicz ; Khalaf Bushara ; Michael Geschwind ; Guangbin Xia ; S H Subramony ; Tetsuo Ashizawa ; Sheng-Han KuoSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Disease Progression, Female, Humans, Huntington Disease (drug therapy), Male, Middle Aged, Questionnaires, Severity of Illness Index, Spinocerebellar Ataxias (diagnosis), Spinocerebellar Ataxias (drug therapy), Treatment Outcome, Ubiquinone (analogs & derivatives), Ubiquinone (therapeutic use).
- MESH :
- chemical , analogs & derivatives : Ubiquinone.
- diagnosis : Spinocerebellar Ataxias.
- drug therapy : Huntington Disease, Spinocerebellar Ataxias.
- chemical , therapeutic use : Ubiquinone.
- Adult, Age of Onset, Aged, Disease Progression, Female, Humans, Male, Middle Aged, Questionnaires, Severity of Illness Index, Treatment Outcome.
Abstract
The aim of this study was to investigate the association between drug exposure and disease severity in SCA types 1, 2, 3 and 6. The Clinical Research Consortium for Spinocerebellar Ataxias (CRC-SCA) enrolled 319 participants with SCA1, 2, 3, and 6 from 12 medical centers in the United States and repeatedly measured clinical severity by the Scale for Assessment and Rating of Ataxia (SARA), the Unified Huntington's Disease Rating Scale part IV (UHDRS-IV), and the 9-item Patient Health Questionnaire during July 2009 to May 2012. We employed generalized estimating equations in regression models to study the longitudinal effects of coenzyme Q10 (CoQ10), statin, and vitamin E on clinical severity of ataxia after adjusting for age, sex, and pathological CAG repeat number. Cross-sectionally, exposure to CoQ10 was associated with lower SARA and higher UHDRS-IV scores in SCA1 and 3. No association was found between statins, vitamin E, and clinical outcome. Longitudinally, CoQ10, statins, and vitamin E did not change the rates of clinical deterioration indexed by SARA and UHDRS-IV scores within 2 years. CoQ10 is associated with better clinical outcome in SCA1 and 3. These drug exposures did not appear to influence clinical progression within 2 years. Further studies are warranted to confirm the association.
DOI: 10.1002/mds.26088
PubMed: 25449974
Affiliations:
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Pulst</name></author><author><name sortKey="Lin, Chi Ying" sort="Lin, Chi Ying" uniqKey="Lin C" first="Chi-Ying" last="Lin">Chi-Ying Lin</name></author><author><name sortKey="Perlman, Susan" sort="Perlman, Susan" uniqKey="Perlman S" first="Susan" last="Perlman">Susan Perlman</name></author><author><name sortKey="Wilmot, George" sort="Wilmot, George" uniqKey="Wilmot G" first="George" last="Wilmot">George Wilmot</name></author><author><name sortKey="Gomez, Christopher" sort="Gomez, Christopher" uniqKey="Gomez C" first="Christopher" last="Gomez">Christopher Gomez</name></author><author><name sortKey="Schmahmann, Jeremy" sort="Schmahmann, Jeremy" uniqKey="Schmahmann J" first="Jeremy" last="Schmahmann">Jeremy Schmahmann</name></author><author><name sortKey="Paulson, Henry" sort="Paulson, Henry" uniqKey="Paulson H" first="Henry" last="Paulson">Henry Paulson</name></author><author><name sortKey="Shakkottai, Vikram G" sort="Shakkottai, Vikram G" uniqKey="Shakkottai V" first="Vikram G" last="Shakkottai">Vikram G. Shakkottai</name></author><author><name sortKey="Ying, Sarah" sort="Ying, Sarah" uniqKey="Ying S" first="Sarah" last="Ying">Sarah Ying</name></author><author><name sortKey="Zesiewicz, Theresa" sort="Zesiewicz, Theresa" uniqKey="Zesiewicz T" first="Theresa" last="Zesiewicz">Theresa Zesiewicz</name></author><author><name sortKey="Bushara, Khalaf" sort="Bushara, Khalaf" uniqKey="Bushara K" first="Khalaf" last="Bushara">Khalaf Bushara</name></author><author><name sortKey="Geschwind, Michael" sort="Geschwind, Michael" uniqKey="Geschwind M" first="Michael" last="Geschwind">Michael Geschwind</name></author><author><name sortKey="Xia, Guangbin" sort="Xia, Guangbin" uniqKey="Xia G" first="Guangbin" last="Xia">Guangbin Xia</name></author><author><name sortKey="Subramony, S H" sort="Subramony, S H" uniqKey="Subramony S" first="S H" last="Subramony">S H Subramony</name></author><author><name sortKey="Ashizawa, Tetsuo" sort="Ashizawa, Tetsuo" uniqKey="Ashizawa T" first="Tetsuo" last="Ashizawa">Tetsuo Ashizawa</name></author><author><name sortKey="Kuo, Sheng Han" sort="Kuo, Sheng Han" uniqKey="Kuo S" first="Sheng-Han" last="Kuo">Sheng-Han Kuo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25449974</idno><idno type="pmid">25449974</idno><idno type="doi">10.1002/mds.26088</idno><idno type="wicri:Area/PubMed/Corpus">000335</idno><idno type="wicri:Area/PubMed/Curation">000335</idno><idno type="wicri:Area/PubMed/Checkpoint">000293</idno><idno type="wicri:Area/Ncbi/Merge">004174</idno><idno type="wicri:Area/Ncbi/Curation">004174</idno><idno type="wicri:Area/Ncbi/Checkpoint">004174</idno><idno type="wicri:Area/Main/Merge">000292</idno><idno type="wicri:Area/Main/Curation">000292</idno><idno type="wicri:Area/Main/Exploration">000292</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Coenzyme Q10 and spinocerebellar ataxias.</title><author><name sortKey="Lo, Raymond Y" sort="Lo, Raymond Y" uniqKey="Lo R" first="Raymond Y" last="Lo">Raymond Y. Lo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Neurology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien</wicri:regionArea><wicri:noRegion>Hualien</wicri:noRegion></affiliation></author><author><name sortKey="Figueroa, Karla P" sort="Figueroa, Karla P" uniqKey="Figueroa K" first="Karla P" last="Figueroa">Karla P. Figueroa</name></author><author><name sortKey="Pulst, Stefan M" sort="Pulst, Stefan M" uniqKey="Pulst S" first="Stefan M" last="Pulst">Stefan M. Pulst</name></author><author><name sortKey="Lin, Chi Ying" sort="Lin, Chi Ying" uniqKey="Lin C" first="Chi-Ying" last="Lin">Chi-Ying Lin</name></author><author><name sortKey="Perlman, Susan" sort="Perlman, Susan" uniqKey="Perlman S" first="Susan" last="Perlman">Susan Perlman</name></author><author><name sortKey="Wilmot, George" sort="Wilmot, George" uniqKey="Wilmot G" first="George" last="Wilmot">George Wilmot</name></author><author><name sortKey="Gomez, Christopher" sort="Gomez, Christopher" uniqKey="Gomez C" first="Christopher" last="Gomez">Christopher Gomez</name></author><author><name sortKey="Schmahmann, Jeremy" sort="Schmahmann, Jeremy" uniqKey="Schmahmann J" first="Jeremy" last="Schmahmann">Jeremy Schmahmann</name></author><author><name sortKey="Paulson, Henry" sort="Paulson, Henry" uniqKey="Paulson H" first="Henry" last="Paulson">Henry Paulson</name></author><author><name sortKey="Shakkottai, Vikram G" sort="Shakkottai, Vikram G" uniqKey="Shakkottai V" first="Vikram G" last="Shakkottai">Vikram G. Shakkottai</name></author><author><name sortKey="Ying, Sarah" sort="Ying, Sarah" uniqKey="Ying S" first="Sarah" last="Ying">Sarah Ying</name></author><author><name sortKey="Zesiewicz, Theresa" sort="Zesiewicz, Theresa" uniqKey="Zesiewicz T" first="Theresa" last="Zesiewicz">Theresa Zesiewicz</name></author><author><name sortKey="Bushara, Khalaf" sort="Bushara, Khalaf" uniqKey="Bushara K" first="Khalaf" last="Bushara">Khalaf Bushara</name></author><author><name sortKey="Geschwind, Michael" sort="Geschwind, Michael" uniqKey="Geschwind M" first="Michael" last="Geschwind">Michael Geschwind</name></author><author><name sortKey="Xia, Guangbin" sort="Xia, Guangbin" uniqKey="Xia G" first="Guangbin" last="Xia">Guangbin Xia</name></author><author><name sortKey="Subramony, S H" sort="Subramony, S H" uniqKey="Subramony S" first="S H" last="Subramony">S H Subramony</name></author><author><name sortKey="Ashizawa, Tetsuo" sort="Ashizawa, Tetsuo" uniqKey="Ashizawa T" first="Tetsuo" last="Ashizawa">Tetsuo Ashizawa</name></author><author><name sortKey="Kuo, Sheng Han" sort="Kuo, Sheng Han" uniqKey="Kuo S" first="Sheng-Han" last="Kuo">Sheng-Han Kuo</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Huntington Disease (drug therapy)</term><term>Male</term><term>Middle Aged</term><term>Questionnaires</term><term>Severity of Illness Index</term><term>Spinocerebellar Ataxias (diagnosis)</term><term>Spinocerebellar Ataxias (drug therapy)</term><term>Treatment Outcome</term><term>Ubiquinone (analogs & derivatives)</term><term>Ubiquinone (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Ubiquinone</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Spinocerebellar Ataxias</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Huntington Disease</term><term>Spinocerebellar Ataxias</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Ubiquinone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Questionnaires</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to investigate the association between drug exposure and disease severity in SCA types 1, 2, 3 and 6. The Clinical Research Consortium for Spinocerebellar Ataxias (CRC-SCA) enrolled 319 participants with SCA1, 2, 3, and 6 from 12 medical centers in the United States and repeatedly measured clinical severity by the Scale for Assessment and Rating of Ataxia (SARA), the Unified Huntington's Disease Rating Scale part IV (UHDRS-IV), and the 9-item Patient Health Questionnaire during July 2009 to May 2012. We employed generalized estimating equations in regression models to study the longitudinal effects of coenzyme Q10 (CoQ10), statin, and vitamin E on clinical severity of ataxia after adjusting for age, sex, and pathological CAG repeat number. Cross-sectionally, exposure to CoQ10 was associated with lower SARA and higher UHDRS-IV scores in SCA1 and 3. No association was found between statins, vitamin E, and clinical outcome. Longitudinally, CoQ10, statins, and vitamin E did not change the rates of clinical deterioration indexed by SARA and UHDRS-IV scores within 2 years. CoQ10 is associated with better clinical outcome in SCA1 and 3. These drug exposures did not appear to influence clinical progression within 2 years. Further studies are warranted to confirm the association.</div></front></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Ashizawa, Tetsuo" sort="Ashizawa, Tetsuo" uniqKey="Ashizawa T" first="Tetsuo" last="Ashizawa">Tetsuo Ashizawa</name><name sortKey="Bushara, Khalaf" sort="Bushara, Khalaf" uniqKey="Bushara K" first="Khalaf" last="Bushara">Khalaf Bushara</name><name sortKey="Figueroa, Karla P" sort="Figueroa, Karla P" uniqKey="Figueroa K" first="Karla P" last="Figueroa">Karla P. Figueroa</name><name sortKey="Geschwind, Michael" sort="Geschwind, Michael" uniqKey="Geschwind M" first="Michael" last="Geschwind">Michael Geschwind</name><name sortKey="Gomez, Christopher" sort="Gomez, Christopher" uniqKey="Gomez C" first="Christopher" last="Gomez">Christopher Gomez</name><name sortKey="Kuo, Sheng Han" sort="Kuo, Sheng Han" uniqKey="Kuo S" first="Sheng-Han" last="Kuo">Sheng-Han Kuo</name><name sortKey="Lin, Chi Ying" sort="Lin, Chi Ying" uniqKey="Lin C" first="Chi-Ying" last="Lin">Chi-Ying Lin</name><name sortKey="Paulson, Henry" sort="Paulson, Henry" uniqKey="Paulson H" first="Henry" last="Paulson">Henry Paulson</name><name sortKey="Perlman, Susan" sort="Perlman, Susan" uniqKey="Perlman S" first="Susan" last="Perlman">Susan Perlman</name><name sortKey="Pulst, Stefan M" sort="Pulst, Stefan M" uniqKey="Pulst S" first="Stefan M" last="Pulst">Stefan M. Pulst</name><name sortKey="Schmahmann, Jeremy" sort="Schmahmann, Jeremy" uniqKey="Schmahmann J" first="Jeremy" last="Schmahmann">Jeremy Schmahmann</name><name sortKey="Shakkottai, Vikram G" sort="Shakkottai, Vikram G" uniqKey="Shakkottai V" first="Vikram G" last="Shakkottai">Vikram G. Shakkottai</name><name sortKey="Subramony, S H" sort="Subramony, S H" uniqKey="Subramony S" first="S H" last="Subramony">S H Subramony</name><name sortKey="Wilmot, George" sort="Wilmot, George" uniqKey="Wilmot G" first="George" last="Wilmot">George Wilmot</name><name sortKey="Xia, Guangbin" sort="Xia, Guangbin" uniqKey="Xia G" first="Guangbin" last="Xia">Guangbin Xia</name><name sortKey="Ying, Sarah" sort="Ying, Sarah" uniqKey="Ying S" first="Sarah" last="Ying">Sarah Ying</name><name sortKey="Zesiewicz, Theresa" sort="Zesiewicz, Theresa" uniqKey="Zesiewicz T" first="Theresa" last="Zesiewicz">Theresa Zesiewicz</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Lo, Raymond Y" sort="Lo, Raymond Y" uniqKey="Lo R" first="Raymond Y" last="Lo">Raymond Y. Lo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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